Pertussis toxin from Bordetella pertussis
| 型 号： | P7208 |
| 报 价： | 4942 |
sigma Pertussis toxin from Bordela pertussisP7208 CAS号: 70323-44-3
- 产品描述
品名：Pertussis toxin from Bordela pertussis
货号：P7208 lyophilized powder
别名: Histamine-sensitizing factor, IAP, Islet Activating Protein, Pertussigen ，CAS号: 70323-44-3
产品简要说明：
相关类型 | Bacteria, Bacteria-derived adjuvants, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, G Protein Function, G Proteins and Cyclic Nucleotides, P, Reagents, Toxins and Venoms, Vaccine Adjuvants, Vaccine Production more... |
form | lyophilized powder |
storage temp. | 2-8°C |
storage temp. | 2-8°C |
保存温度：2-8°C
货期：两到三周，每周周二周五订单日。
General description
Product is not activated. If activation is required, see Kaslow, et al., for suggested conditions.
Physical form
Lyophilized powder containing sodium chloride and sodium phosphate buffer salts
Application
The toxin is released from B. pertussis in an inactive form. When the pertussis toxin B oligomer binds to the cell membrane, the S1 subunit of its A protomer becomes activated, perhaps through the action of glutathione and ATP. A protocol for activating pertussis toxin in vitro is given by Kaslow, et al.
Biochem/physiol Actions
Pertussis toxin catalyzes the ADP-ribosylation of the α subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt. This prevents the G protein heterotrimers from interacting with receptors, thus blocking their coupling and activation. Since the Gα subunits remain in their GDP-bound, inactive state, they are unable to inactivate adenylyl cyclase or open K+ channels.
